Prof. Dr. rer. nat. Christine Heim

Expertise

• Entwicklungsbezogene Psychobiologie, i.S. der Folgen von frühen aversiven Lebenserfahrungen
• Neurobiologie der Depression und Angststörungen, i.S. der Posttraumatischen Belastungsstörung
• Psychoneuroendokrinologie von funktionellen somatischen Syndromen
• Neuronale Korrelate von Stress und Emotionen
• Interaktionen von Stress und dispositionellen Faktoren im Laufe der Entwicklung

Kontakt:

christine.heim(at)charite.de

Additional information

Research Impact:

• Impact Factor: 495
• Zitationen (Google Scholar): >21,400
• H-Index (Google Scholar): 57
• H-Index (Web of Science): 41
• H-Index (Research Gate): 54
• RG Score: 42.2 (Perzentil >97.5 )

Ausgewählte Publikationen:

• Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, Schalkwyk LC, Creyghton MP, Kahn RS, Joëls M, Binder EB, Boks MP. Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun 2016;7:10967.
• Heim C, Mayberg HS, Mletzko T, Nemeroff CB, Pruessner JC. Decreased cortical representation of genital somatosensory field after childhood sexual abuse. Am J Psychiatry 2013;170:616-623.
• Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace, TWW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB. Allele-specific DNA demethylation in FKBP5: a molecular mediator of gene x childhood trauma interactions. Nature Neuroscience 2013;16:33-41.

• Lupien SJ, McEwen BS, Gunnar M, Heim C. Effects of stress throughout the lifespan on brain, behavior and cognition. Nature Rev Neurosci  2009;10:434-445.

• Heim C, Nater UM, Maloney EB, Boneva R, Jones JF, Reeves WC. Childhood trauma and risk for chronic fatigue syndrome: Association with neuroendocrine dysfunction. Arch Gen Psychiatry 2009;66: 72-80.

• Heim C, Young LJ, Newport DJ, Mletzko TC, Miller AH, Nemeroff CB. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol Psychiatry 2009;14: 954-958.

• Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim C, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008;299: 1291-1305.

• Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim C, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008;65: 190-200.

• Heim C, Mletzko T, Purselle D, Musselman D, Nemeroff CB. The dexamethasone/CRF test in men with major depression: Role of childhood trauma. Biol Psychiatry 2008;63: 398-405.

• Heim C, Plotsky PM, Nemeroff CB. The importance of evaluating the contributions of early adverse experience to the neurobiology of depression. Neuropsychopharmacology 2004;29: 641–648.
• Nemeroff CB, Heim C, Thase ME, Rush AJ, Schatzberg AF, Ninan PT, Klein DN, McCullough JP, Weiss P, Dunner DL, Rothbaum BO, Kornstein S, Keitner G, Keller MB. Differential responses to psychotherapy versus pharmacotherapy in the treatment of patients with chronic forms of major depression and childhood trauma. Proc Nat Acad Sci USA 2003;100: 14293-14296. PMCID: PMC283585

• Vythilingam M, Heim C, Newport DJ, Miller AH, Vermetten E, Anderson E, Bronen R, Staib L, Charney DS, Nemeroff CB, Bremner JD. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 2002;159: 2072-2080.
• Heim C, Binder EB. Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Experimental Neurology 2001;233:102-111.
• Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatry 2001;158: 575-581.
• Heim C, Nemeroff CB. The role of childhood trauma in the neurobiology of mood and anxiety disorders: Pre-clinical and clinical studies. Biol Psychiatry 2001;49: 1023-1039.
• Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, Miller AH, Nemeroff CB. Increased pituitary-adrenal and autonomic responses to stress in adult women after sexual and physical abuse in childhood. JAMA 2000; 284: 592-597.
• Heim C, Ehlert U, Hellhammer DH. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000;25: 1-35.

Außenstandort:

Pennsylvania State University
109 Biobehavioral Health Building
University Park PA 16802
814-863-7256

Networking

Neurology, Neurosurgery and Psychiatry (CC 15)

Campus Charité Mitte
(CCM)